In vivo Anticoccidial Efficacy of Calotropis procera Leaf Extract as an Alternative Treatment Against Eimeria papillate Infection in Mice

Background: Coccidiosis is still a serious parasite illness caused by Eimeria pps in many areas throughout the globe. As consequence of eimeria medication resistance. needs new drugs that contain natural antiparasitic chemical compounds. This study was conducted to investigate vivo anti-coccidia activity Calotropis pocera leaf extract (CPLE) against infection mice with papillate. Methods: The first and second mouse groups were not infected, while third, fourth, fifth sixth given 1x103 E. papillate sporulated oocysts. fourth received 100 200 mg/kg CPLE orally toltrazuril 25 physiological saline. On day 5 p.i., animals slaughtered jejunum samples prepared. Result: phytochemistry revealed 13 most efficacious dose, reducing oocyst discharge faces 68% stages jejunal sections. Infection papillata causes inflammation, epithelial vacuolation, villi loss decrease goblet cell density. When infected CPLE, histological damage reduced 69% number restored near-control levels. group lost weight owing emesis. However, treated gained weight.